Salt-inducible kinases (SIK) inhibition reduces RANKL-induced osteoclastogenesis.

Salt-inducible kinases (SIK) inhibition reduces RANKL-induced osteoclastogenesis.

Osteoclasts are large multinucleated cells responsible for bone resorption. Excessive inflammatory activation of osteoclasts leads to bony erosions, which are the hallmark of several diseases such as rheumatoid arthritis (RA). Salt-inducible kinases (SIK) constitute a subfamily of kinases comprising...

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Bibliographic Details
Main Authors: Maria Stella Lombardi, Corine Gilliéron, Majoska Berkelaar, Cem Gabay
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5626034?pdf=render

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http://europepmc.org/articles/PMC5626034?pdf=render

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