Silencing rapsyn in vivo decreases acetylcholine receptors and augments sodium channels and secondary postsynaptic membrane folding

Silencing rapsyn in vivo decreases acetylcholine receptors and augments sodium channels and secondary postsynaptic membrane folding

The receptor-associated protein of the synapse (rapsyn) is required for anchoring and stabilizing the nicotinic acetylcholine receptor (AChR) in the postsynaptic membrane of the neuromuscular junction (NMJ) during development. Here we studied the role of rapsyn in the maintenance of the adult NMJ by...

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Bibliographic Details
Main Authors: Pilar Martínez-Martínez, Marko Phernambucq, Laura Steinbusch, Laurent Schaeffer, Sonia Berrih-Aknin, Hans Duimel, Peter Frederik, Peter Molenaar, Marc H. De Baets, Mario Losen
Format: Article
Language:English
Published: Elsevier 2009-07-01
Series:Neurobiology of Disease
Subjects:
Rapsyn
Voltage gated sodium channel
Myasthenia gravis
Neuromuscular junction
Congenital myasthenic syndromes
Online Access:http://www.sciencedirect.com/science/article/pii/S096999610900059X

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http://www.sciencedirect.com/science/article/pii/S096999610900059X

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