Analysis of proarrhythmic potential of an atypical antipsychotic drug paliperidone in the halothane-anesthetized dogs

Analysis of proarrhythmic potential of an atypical antipsychotic drug paliperidone in the halothane-anesthetized dogs

Fatal cases with the use of atypical antipsychotic drug paliperidone have been reported; however, there was no clinical report describing paliperidone-induced torsade de pointes. In this study we assessed its electropharmacological effects together with its proarrhythmic potential in intravenous dos...

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Bibliographic Details
Main Authors: Koki Chiba, Takeshi Wada, Yuji Nakamura, Xin Cao, Mihoko Hagiwara-Nagasawa, Hiroko Izumi-Nakaseko, Kentaro Ando, Koichiro Tanaka, Atsuhiko T. Naito, Atsushi Sugiyama
Format: Article
Language:English
Published: Elsevier 2017-08-01
Series:Journal of Pharmacological Sciences
Subjects:
Paliperidone
Proarrhythmic potential
Early repolarization
Late repolarization
Short-term variability
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861317301135

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http://www.sciencedirect.com/science/article/pii/S1347861317301135

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