Synaptic Regulation of a Thalamocortical Circuit Controls Depression-Related Behavior

Synaptic Regulation of a Thalamocortical Circuit Controls Depression-Related Behavior

The NMDA receptor (NMDAR) antagonist ketamine elicits a long-lasting antidepressant response in patients with treatment-resistant depression. Understanding how antagonism of NMDARs alters synapse and circuit function is pivotal to developing circuit-based therapies for depression. Using virally indu...

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Bibliographic Details
Main Authors: Oliver H. Miller, Andreas Bruns, Imen Ben Ammar, Thomas Mueggler, Benjamin J. Hall
Format: Article
Language:English
Published: Elsevier 2017-08-01
Series:Cell Reports
Subjects:
NMDAR
GluN2B
motivation
ketamine
depression
medial dorsal thalamus
optogenetics
chemogenetics
thalamocortical
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717310719

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http://www.sciencedirect.com/science/article/pii/S2211124717310719

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