Complement C5a is detrimental to histological and functional locomotor recovery after spinal cord injury in mice

Complement C5a is detrimental to histological and functional locomotor recovery after spinal cord injury in mice

Based on the studies on the role of complements C3, C1q and factor B, we hypothesized that complement C5a is detrimental to locomotor recovery at the early stage of secondary injury after spinal cord injury (SCI). To test this hypothesis, we investigated the effect of inhibition of complement C5a re...

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Bibliographic Details
Main Authors: Lan Li, Zhi-yong Xiong, Zhong Ming Qian, Tian-zhi Zhao, Hua Feng, Sengli Hu, Rong Hu, Ya Ke, Jiangkai Lin
Format: Article
Language:English
Published: Elsevier 2014-06-01
Series:Neurobiology of Disease
Subjects:
Spinal cord injury (SCI)
Complement C5a receptor antagonist (C5aRA)
BALB/c C5aR mice (C5aR−/−)
Basso mouse scale (BMS)
Microglia/macrophage
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114000503

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http://www.sciencedirect.com/science/article/pii/S0969996114000503

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