Anti-neuroinflammation ameliorates systemic inflammation-induced mitochondrial DNA impairment in the nucleus of the solitary tract and cardiovascular reflex dysfunction

Anti-neuroinflammation ameliorates systemic inflammation-induced mitochondrial DNA impairment in the nucleus of the solitary tract and cardiovascular reflex dysfunction

Abstract Background Decreased heart rate variability (HRV) leads to cardiovascular diseases and increased mortality in clinical studies. However, the underlying mechanisms are still inconclusive. Systemic inflammation-induced neuroinflammation is known to impair the autonomic center of cardiovascula...

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Bibliographic Details
Main Authors: Mu-Hui Fu, I-Chun Chen, Chou-Hwei Lee, Chih-Wei Wu, Yu-Chi Lee, Yu Chih Kung, Chun-Ying Hung, Kay L. H. Wu
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Journal of Neuroinflammation
Subjects:
Systemic inflammation
Neuroinflammation
Proinflammatory cytokines
mtDNA damage
mtDNA repairment
Baroreflex
Online Access:http://link.springer.com/article/10.1186/s12974-019-1623-0

Internet

http://link.springer.com/article/10.1186/s12974-019-1623-0

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