Unprecedented in Vitro Antitubercular Activitiy of Manganese(II) Complexes Containing 1,10-Phenanthroline and Dicarboxylate Ligands: Increased Activity, Superior Selectivity, and Lower Toxicity in Comparison to Their Copper(II) Analogs

Unprecedented in Vitro Antitubercular Activitiy of Manganese(II) Complexes Containing 1,10-Phenanthroline and Dicarboxylate Ligands: Increased Activity, Superior Selectivity, and Lower Toxicity in Comparison to Their Copper(II) Analogs

Mycobacterium tuberculosis is the etiologic agent of tuberculosis. The demand for new chemotherapeutics with unique mechanisms of action to treat (multi)resistant strains is an urgent need. The objective of this work was to test the effect of manganese(II) and copper(II) phenanthroline/dicarboxylate...

Full description

Bibliographic Details
Main Authors: Pauraic McCarron, Malachy McCann, Michael Devereux, Kevin Kavanagh, Ciaran Skerry, Petros C. Karakousis, Ana C. Aor, Thaís P. Mello, André L. S. Santos, Débora L. Campos, Fernando R. Pavan
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Microbiology
Subjects:
Mycobacterium tuberculosis
manganese(II)
1
10-phenanthroline
metal-based complex
antimicrobial agent
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.01432/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2018.01432/full

Similar Items