Identification of KIF3A as a novel candidate gene for childhood asthma using RNA expression and population allelic frequencies differences.

Identification of KIF3A as a novel candidate gene for childhood asthma using RNA expression and population allelic frequencies differences.

Asthma is a chronic inflammatory disease with a strong genetic predisposition. A major challenge for candidate gene association studies in asthma is the selection of biologically relevant genes.Using epithelial RNA expression arrays, HapMap allele frequency variation, and the literature, we identifi...

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Bibliographic Details
Main Authors: Melinda Butsch Kovacic, Jocelyn M Biagini Myers, Ning Wang, Lisa J Martin, Mark Lindsey, Mark B Ericksen, Hua He, Tia L Patterson, Tesfaye M Baye, Dara Torgerson, Lindsey A Roth, Jayanta Gupta, Umasundari Sivaprasad, Aaron M Gibson, Anna M Tsoras, Donglei Hu, Celeste Eng, Rocío Chapela, José R Rodríguez-Santana, William Rodríguez-Cintrón, Pedro C Avila, Kenneth Beckman, Max A Seibold, Chris Gignoux, Salma M Musaad, Weiguo Chen, Esteban González Burchard, Gurjit K Khurana Hershey
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3166061?pdf=render

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http://europepmc.org/articles/PMC3166061?pdf=render

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