Intrinsic disorder within AKAP79 fine-tunes anchored phosphatase activity toward substrates and drug sensitivity

Intrinsic disorder within AKAP79 fine-tunes anchored phosphatase activity toward substrates and drug sensitivity

Scaffolding the calcium/calmodulin-dependent phosphatase 2B (PP2B, calcineurin) focuses and insulates termination of local second messenger responses. Conformational flexibility in regions of intrinsic disorder within A-kinase anchoring protein 79 (AKAP79) delineates PP2B access to phosphoproteins....

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Bibliographic Details
Main Authors: Patrick J Nygren, Sohum Mehta, Devin K Schweppe, Lorene K Langeberg, Jennifer L Whiting, Chad R Weisbrod, James E Bruce, Jin Zhang, David Veesler, John D Scott
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-10-01
Series:eLife
Subjects:
anchoring proteins
AKAP79
calcineurin/PP2B
calcium signaling
intrinsic disorder
short linear motifs
Online Access:https://elifesciences.org/articles/30872

Internet

https://elifesciences.org/articles/30872

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