Increased infiltration of M2-macrophages, T-cells and PD-L1 expression in high grade leiomyosarcomas supports immunotherapeutic strategies

Increased infiltration of M2-macrophages, T-cells and PD-L1 expression in high grade leiomyosarcomas supports immunotherapeutic strategies

Background: Immunotherapy may be a rational strategy in leiomyosarcoma (LMS), a tumor known for its genomic complexity. As a prerequisite for therapeutic applications, we characterized the immune microenvironment in LMS, as well as its prognostic value. Methods: CD163+ macrophages, CD3+ T-cells, PD-...

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Bibliographic Details
Main Authors: Marie Kostine, Inge H. Briaire-de Bruijn, Arjen H. G. Cleven, Carly Vervat, Willem E. Corver, Marco W. Schilham, Els Van Beelen, Hester van Boven, Rick L. Haas, Antoine Italiano, Anne-Marie Cleton-Jansen, Judith V. M. G. Bovée
Format: Article
Language:English
Published: Taylor & Francis Group 2018-02-01
Series:OncoImmunology
Subjects:
leiomyosarcoma
tumor-associated macrophages
tumor-infiltrating lymphocytes
hla
pd-l1, immunotherapy
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1386828

Internet

http://dx.doi.org/10.1080/2162402X.2017.1386828

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