Integrating Enhancer Mechanisms to Establish a Hierarchical Blood Development Program

Integrating Enhancer Mechanisms to Establish a Hierarchical Blood Development Program

Hematopoietic development requires the transcription factor GATA-2, and GATA-2 mutations cause diverse pathologies, including leukemia. GATA-2-regulated enhancers increase Gata2 expression in hematopoietic stem/progenitor cells and control hematopoiesis. The +9.5-kb enhancer activates transcription...

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Bibliographic Details
Main Authors: Charu Mehta, Kirby D. Johnson, Xin Gao, Irene M. Ong, Koichi R. Katsumura, Skye C. McIver, Erik A. Ranheim, Emery H. Bresnick
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Cell Reports
Subjects:
GATA-2
enhancer
hematopoiesis
erythroid
myeloid
progenitor
mouse model
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717312329

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http://www.sciencedirect.com/science/article/pii/S2211124717312329

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