Discrete spatial organization of TGFβ receptors couples receptor multimerization and signaling to cellular tension

Discrete spatial organization of TGFβ receptors couples receptor multimerization and signaling to cellular tension

Cell surface receptors are central to the cell's ability to generate coordinated responses to the multitude of biochemical and physical cues in the microenvironment. However, the mechanisms by which receptors enable this concerted cellular response remain unclear. To investigate the effect of c...

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Bibliographic Details
Main Authors: Joanna P Rys, Christopher C DuFort, David A Monteiro, Michelle A Baird, Juan A Oses-Prieto, Shreya Chand, Alma L Burlingame, Michael W Davidson, Tamara N Alliston
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-12-01
Series:eLife
Subjects:
TGFβ receptor
integrin
spatial organization
focal adhesion
cellular tension
Online Access:https://elifesciences.org/articles/09300

Internet

https://elifesciences.org/articles/09300

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