Human leukocyte antigen genes and interferon beta preparations influence risk of developing neutralizing anti-drug antibodies in multiple sclerosis.

Human leukocyte antigen genes and interferon beta preparations influence risk of developing neutralizing anti-drug antibodies in multiple sclerosis.

A significant proportion of patients with multiple sclerosis who receive interferon beta (IFNβ) therapy develop neutralizing antibodies (NAbs) that reduce drug efficacy. To investigate if HLA class I and II alleles are associated with development of NAbs against IFNβ we analyzed whether NAb status a...

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Bibliographic Details
Main Authors: Jenny Link, Malin Lundkvist Ryner, Katharina Fink, Christina Hermanrud, Izaura Lima, Boel Brynedal, Ingrid Kockum, Jan Hillert, Anna Fogdell-Hahn
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3946519?pdf=render

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http://europepmc.org/articles/PMC3946519?pdf=render

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