T cell inactivation by poxviral B22 family proteins increases viral virulence.

T cell inactivation by poxviral B22 family proteins increases viral virulence.

Infections with monkeypox, cowpox and weaponized variola virus remain a threat to the increasingly unvaccinated human population, but little is known about their mechanisms of virulence and immune evasion. We now demonstrate that B22 proteins, encoded by the largest genes of these viruses, render hu...

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Bibliographic Details
Main Authors: Dina Alzhanova, Erika Hammarlund, Jason Reed, Erin Meermeier, Stephanie Rawlings, Caroline A Ray, David M Edwards, Ben Bimber, Alfred Legasse, Shannon Planer, Jerald Sprague, Michael K Axthelm, David J Pickup, David M Lewinsohn, Marielle C Gold, Scott W Wong, Jonah B Sacha, Mark K Slifka, Klaus Früh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-05-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4022744?pdf=render

Internet

http://europepmc.org/articles/PMC4022744?pdf=render

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