Exogenous angiotensin (1-7) directly inhibits epithelial-mesenchymal transformation induced by transforming growth factor-β1 in alveolar epithelial cells

Exogenous angiotensin (1-7) directly inhibits epithelial-mesenchymal transformation induced by transforming growth factor-β1 in alveolar epithelial cells

Accumulating evidence indicates that angiotensin (1-7) [Ang-(1-7)] protects against idiopathic pulmonary fibrosis (IPF) in animal experiments. However, whether Ang-(1-7) effectively inhibits epithelial-mesenchymal transition (EMT) induced by transforming growth factor-β1 (TGF-β1) remains unclear. Th...

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Bibliographic Details
Main Authors: Min Shao, Zhi-Bin Wen, Hui-Hui Yang, Chen-Yu Zhang, Jian-Bing Xiong, Xin-Xin Guan, Wen-Jing Zhong, Hui-Ling Jiang, Chen-Chen Sun, Xiao-Qin Luo, Xiao-Fan He, Yong Zhou, Cha-Xiang Guan
Format: Article
Language:English
Published: Elsevier 2019-09-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Angiotensin (1-7)
Epithelial-mesenchymal transition
Transforming growth factor-β1
Angiotensin converting enzyme 2
Alveolar epithelial cells
Online Access:http://www.sciencedirect.com/science/article/pii/S075333221931193X

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http://www.sciencedirect.com/science/article/pii/S075333221931193X

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