Exogenous angiotensin (1-7) directly inhibits epithelial-mesenchymal transformation induced by transforming growth factor-β1 in alveolar epithelial cells

Exogenous angiotensin (1-7) directly inhibits epithelial-mesenchymal transformation induced by transforming growth factor-β1 in alveolar epithelial cells

Accumulating evidence indicates that angiotensin (1-7) [Ang-(1-7)] protects against idiopathic pulmonary fibrosis (IPF) in animal experiments. However, whether Ang-(1-7) effectively inhibits epithelial-mesenchymal transition (EMT) induced by transforming growth factor-β1 (TGF-β1) remains unclear. Th...

Full description

Bibliographic Details
Main Authors:	Min Shao, Zhi-Bin Wen, Hui-Hui Yang, Chen-Yu Zhang, Jian-Bing Xiong, Xin-Xin Guan, Wen-Jing Zhong, Hui-Ling Jiang, Chen-Chen Sun, Xiao-Qin Luo, Xiao-Fan He, Yong Zhou, Cha-Xiang Guan
Format:	Article
Language:	English
Published:	Elsevier 2019-09-01
Series:	Biomedicine & Pharmacotherapy
Subjects:	Angiotensin (1-7) Epithelial-mesenchymal transition Transforming growth factor-β1 Angiotensin converting enzyme 2 Alveolar epithelial cells
Online Access:	http://www.sciencedirect.com/science/article/pii/S075333221931193X

Similar Items

The Spike Glycoprotein of SARS-CoV-2 Binds to β1 Integrins Expressed on the Surface of Lung Epithelial Cells
by: Eun Jeong Park, et al.
Published: (2021-04-01)

20(S)-Protopanaxadiol Inhibits Angiotensin II-Induced Epithelial- Mesenchymal Transition by Downregulating SIRT1
by: Yuchen Wang, et al.
Published: (2019-05-01)

YY1 mediates TGF-β1-induced EMT and pro-fibrogenesis in alveolar epithelial cells
by: Chuyi Zhang, et al.
Published: (2019-11-01)

Advances in angiotensin-(1-7) and atrial fibrillation
by: Yan-Guang Miao, et al.
Published: (2019-06-01)

The Key Role of Epithelial to Mesenchymal Transition (EMT) in Hypertensive Kidney Disease
by: Teresa Seccia, et al.
Published: (2019-07-01)

Wnt signaling regulates trans-differentiation of stem cell like type 2 alveolar epithelial cells to type 1 epithelial cells
by: Elhusseiny Mohamed Mahmud Abdelwahab, et al.
Published: (2019-09-01)

Human alveolar epithelial cells type II are capable of TGFβ-dependent epithelial-mesenchymal-transition and collagen-synthesis
by: Torsten Goldmann, et al.
Published: (2018-07-01)

Gas6 Prevents Epithelial-Mesenchymal Transition in Alveolar Epithelial Cells via Production of PGE<sub>2</sub>, PGD<sub>2</sub> and Their Receptors
by: Jihye Jung, et al.
Published: (2019-06-01)

Nicotinamide mononucleotide ameliorates senescence in alveolar epithelial cells
by: Tingting Fang, et al.
Published: (2021-06-01)

Structural determinants for binding to angiotensin converting enzyme 2 (ACE2) and angiotensin receptors
by: Daniel eClayton, et al.
Published: (2015-01-01)

Remodeling of the pulmonary microenvironment controls transforming growth factor-beta activation and alveolar type II epithelial to mesenchymal transition
by: Dysart, Marilyn Markowski
Published: (2015)

Reduced plasma levels of angiotensin-(1-7) and renin activity in preeclamptic patients are associated with the angiotensin I- converting enzyme deletion/deletion genotype
by: E.P. Velloso, et al.

Reduced plasma levels of angiotensin-(1-7) and renin activity in preeclamptic patients are associated with the angiotensin I- converting enzyme deletion/deletion genotype
by: E.P. Velloso, et al.
Published: (2007-04-01)

Alveolar Epithelial Type II Cells as Drivers of Lung Fibrosis in Idiopathic Pulmonary Fibrosis
by: Tanyalak Parimon, et al.
Published: (2020-03-01)

Angiotensin-(1-7) Attenuates Angiotensin II-Induced ICAM-1, VCAM-1, and MCP-1 Expression via the MAS Receptor Through Suppression of P38 and NF-κB Pathways in HUVECs
by: Bin Liang, et al.
Published: (2015-04-01)

Antihypertensive effects of angiotensin-(1-7)
by: M.C. Chappell, et al.
Published: (1998-09-01)

ER Stress is Involved in Epithelial-To-Mesenchymal Transition of Alveolar Epithelial Cells Exposed to a Hypoxic Microenvironment
by: Eva Delbrel, et al.
Published: (2019-03-01)

Role of Renin-Angiotensin System Components in Atherosclerosis: Focus on Ang-II, ACE2, and Ang-1–7
by: Gabriela M. Silva, et al.
Published: (2020-09-01)

Transcriptomic profiling of primary alveolar epithelial cell differentiation in human and rat
by: Crystal N. Marconett, et al.
Published: (2014-12-01)

The role of miRNAs in alveolar epithelial cells in emphysema
by: Hassan Hayek, et al.
Published: (2021-11-01)

Cardiovascular actions of angiotensin-(1-7)
by: Ferreira A.J., et al.
Published: (2005-01-01)

Characterization of air-liquid interface culture of A549 alveolar epithelial cells
by: J. Wu, et al.
Published: (2017-12-01)

Alveolar epithelial glycocalyx shedding aggravates the epithelial barrier and disrupts epithelial tight junctions in acute respiratory distress syndrome
by: Jun Li, et al.
Published: (2021-01-01)

Role of Nonclassical Renin-angiotensin system Axis In Renal Fibrosis
by: Linli eLv, et al.
Published: (2015-04-01)

Nanoparticle Fate in Alveolar Epithelial Cells: Uptake, Distribution and Exocytosis
by: Edward Crandall, et al.
Published: (2020-01-01)

Molecular-genetic assessment of angiotensin-converting enzyme hyperactivity determinancy risk at hemorrhagic fever with renal syndrome
by: A.A. Baygildina, et al.
Published: (2010-03-01)

ACE2 Attenuates Epithelial-Mesenchymal Transition in MLE-12 Cells Induced by Silica
by: Li S, et al.
Published: (2020-04-01)

Angiotensin-converting enzyme 2 and its potential protective effect upon heart
by: Leta Melaku
Published: (2018-01-01)

HO-1 Upregulation by Kaempferol via ROS-Dependent Nrf2-ARE Cascade Attenuates Lipopolysaccharide-Mediated Intercellular Cell Adhesion Molecule-1 Expression in Human Pulmonary Alveolar Epithelial Cells
by: Chen, Y.-W, et al.
Published: (2022)

Dissociation between the circulating renin-angiotensin system and angiotensin II receptors in central losartan-induced hypertension
by: A.M. Sugawara, et al.
Published: (2002-09-01)

Synergism between Angiotensin receptors ligands: Role of Angiotensin‐(1‐7) in modulating AT2R agonist response on nitric oxide in kidney cells
by: Sanket Patel, et al.
Published: (2020-12-01)

Endothelial-monocyte activating polypeptide II disrupts alveolar epithelial type II to type I cell transdifferentiation
by: Chen Yao, et al.
Published: (2012-01-01)

Effect of angiotensin II type 1 receptor blocker and angiotensin converting enzyme inhibitor on the intraocular growth factors and their receptors in streptozotocin-induced diabetic rats
by: Ik Soo Byon, et al.
Published: (2017-06-01)

Correlation between plasma-soluble angiotensin-converting enzyme 2, anti- angiotensin-converting enzyme 2, and angiotensin-(1–7) in patients with chronic heart failure
by: Yi Gu, et al.
Published: (2019-01-01)

The ACE2/Angiotensin-(1–7)/Mas Receptor Axis: Pleiotropic Roles in Cancer
by: Juanjuan Xu, et al.
Published: (2017-05-01)

TO90 inhibits angiotensin II-induced inflammatory response by up-regulating ACE2/Ang-(1-7)/MAS receptor axis in human retinal pigment epithelial cells
by: MAI Yuxin, et al.
Published: (2019-10-01)

Divergence in the activity of the N- and C- catalytic domains of ACE1 - implications for the role of the renin-angiotensin system in Alzheimer’s disease
by: Noura S. AL Mulhim, et al.
Published: (2019-04-01)

Editorial: The Role of the Renin-Angiotensin System in the Central Nervous System
by: Natalia P. Rocha, et al.
Published: (2021-07-01)

Angiotensins and rheumatoid arthritis
by: N. M. Savushkina, et al.
Published: (2019-01-01)

Dexmedetomidine preconditioning protects against lipopolysaccharides-induced injury in the human alveolar epithelial cells
by: Lei Zhang, et al.