Unusually persistent Gαi-signaling of the neuropeptide Y2 receptor depletes cellular Gi/o pools and leads to a Gi-refractory state
Abstract Background A sensitive balance between receptor activation and desensitization is crucial for cellular homeostasis. Like many other GPCR, the human neuropeptide Y2 receptor (hY2R) undergoes ligand dependent activation and internalization into intracellular compartments, followed by recyclin...
Main Authors: | , , , , |
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Format: | Article |
Language: | English |
Published: |
BMC
2020-03-01
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Series: | Cell Communication and Signaling |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12964-020-00537-6 |