Exosomal miR-100-5p inhibits osteogenesis of hBMSCs and angiogenesis of HUVECs by suppressing the BMPR2/Smad1/5/9 signalling pathway

Exosomal miR-100-5p inhibits osteogenesis of hBMSCs and angiogenesis of HUVECs by suppressing the BMPR2/Smad1/5/9 signalling pathway

Abstract Background Nontraumatic osteonecrosis of the femoral head (NONFH) is a common, progressive, and refractory orthopaedic disease. Decreased osteogenesis and angiogenesis are considered the main factors in the pathogenesis of NONFH. We aimed to figure out whether exosomes and exosomal miRNA fr...

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Bibliographic Details
Main Authors: Wu Yang, Weiwen Zhu, Yunfei Yang, Minkang Guo, Husun Qian, Weiqian Jiang, Yu Chen, Chengjie Lian, Zijie Xu, Haobo Bai, Tingmei Chen, Jian Zhang
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Stem Cell Research & Therapy
Subjects:
Nontraumatic osteonecrosis of the femoral head, NONFH
Exosomes
Osteogenic differentiation
Adipocyte differentiation
Angiogenesis
miRNAs
Online Access:https://doi.org/10.1186/s13287-021-02438-y

Internet

https://doi.org/10.1186/s13287-021-02438-y

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