Antibiotic-induced acceleration of type 1 diabetes alters maturation of innate intestinal immunity

Antibiotic-induced acceleration of type 1 diabetes alters maturation of innate intestinal immunity

The early-life intestinal microbiota plays a key role in shaping host immune system development. We found that a single early-life antibiotic course (1PAT) accelerated type 1 diabetes (T1D) development in male NOD mice. The single course had deep and persistent effects on the intestinal microbiome,...

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Bibliographic Details
Main Authors: Xue-Song Zhang, Jackie Li, Kimberly A Krautkramer, Michelle Badri, Thomas Battaglia, Timothy C Borbet, Hyunwook Koh, Sandy Ng, Rachel A Sibley, Yuanyuan Li, Wimal Pathmasiri, Shawn Jindal, Robin R Shields-Cutler, Ben Hillmann, Gabriel A Al-Ghalith, Victoria E Ruiz, Alexandra Livanos, Angélique B van ‘t Wout, Nabeetha Nagalingam, Arlin B Rogers, Susan Jenkins Sumner, Dan Knights, John M Denu, Huilin Li, Kelly V Ruggles, Richard Bonneau, R Anthony Williamson, Marcus Rauch, Martin J Blaser
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-07-01
Series:eLife
Subjects:
microbiome
autoimmune
NOD mice
animal models
immune maturation
gene expression
Online Access:https://elifesciences.org/articles/37816

Internet

https://elifesciences.org/articles/37816

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