Platelet hemostasis in patients with metabolic syndrome and type 2 diabetes mellitus: cGMP- and NO-dependent mechanisms in the insulin-mediated platelet aggregation

Platelet hemostasis in patients with metabolic syndrome and type 2 diabetes mellitus: cGMP- and NO-dependent mechanisms in the insulin-mediated platelet aggregation

Patients with metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM) have high risk of microcirculation complications and microangiopathies. An increase in thrombogenic risk is associated with platelet hyperaggregation, hypercoagulation, and hyperfibrinolysis. Factors leading to platelet acti...

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Bibliographic Details
Main Authors: Tatiana E Suslova, Alexei V Sitozhevskii, Oksana N. Ogurkova, Irina V Kologrivova, Elena S Kravchenko, Yana eAnfinogenova, Rostislav S Karpov
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-01-01
Series:Frontiers in Physiology
Subjects:
Nitric Oxide
Nitric Oxide Synthase
metabolic syndrome
platelets
type 2 diabetes mellitus
cyclic guanosine monophosphate
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00501/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00501/full

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