Regulation of sirtuin function by posttranslational modifications
Sirtuins are homologs of the yeast silencing information regulator 2 (Sir2) protein, an NAD+-dependent (histone) deacetylase. In mammals 7 different sirtuins, SIRT1-7, have been identified, which share a common catalytic core domain but possess distinct N- and C-terminal extensions. This core domain...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2012-02-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00029/full |