Whole-Exome Sequencing Reveals a Rare Variant of OTOF Gene Causing Congenital Non-syndromic Hearing Loss Among Large Muslim Families Favoring Consanguinity

Whole-Exome Sequencing Reveals a Rare Variant of OTOF Gene Causing Congenital Non-syndromic Hearing Loss Among Large Muslim Families Favoring Consanguinity

Non-syndromic hearing loss (NSHL) is one of the most frequent auditory deficits in humans characterized by high clinical and genetic heterogeneity. Very few studies have reported the relationship between OTOF (Locus: DFNB9) and hereditary hearing loss in India. We aimed to decipher the genetic cause...

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Bibliographic Details
Main Authors: Mohd Fareed, Varun Sharma, Inderpal Singh, Sayeed Ur Rehman, Gurdarshan Singh, Mohammad Afzal
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Genetics
Subjects:
hearing disorders
hearing impairment
deaf mutes
autosomal recessive (AR) diseases
cousin marriages
Indian population
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.641925/full

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https://www.frontiersin.org/articles/10.3389/fgene.2021.641925/full

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