Effects of Andrographis paniculata and Orthosiphon stamineus Extracts on the Glucuronidation of 4-Methylumbelliferone in Human UGT Isoforms

Effects of Andrographis paniculata and Orthosiphon stamineus Extracts on the Glucuronidation of 4-Methylumbelliferone in Human UGT Isoforms

The effects of Andrographis paniculata and Orthosiphon stamineus extracts on the in vitro glucuronidation of 4-methylumbelliferone (4MU) by recombinant human UGTs, UGT1A1, UGT1A3, UGT1A6, UGT1A7, UGT1A8, UGT1A10, UGT2B7 and UGT2B15 were determined. The potential inhibitory effects of both of the ext...

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Bibliographic Details
Main Authors: Sabariah Ismail, Nur Aziah Hanapi, Mohd Rohaimi Ab Halim, Verawan Uchaipichat, Peter I. Mackenzie
Format: Article
Language:English
Published: MDPI AG 2010-05-01
Series:Molecules
Subjects:
UGT
inhibition
herbal extracts
Orthosiphon stamineus
Andrographis paniculata
Online Access:http://www.mdpi.com/1420-3049/15/5/3578/

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http://www.mdpi.com/1420-3049/15/5/3578/

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