Targeting thymidine phosphorylase as a potential therapy for bone loss associated with periprosthetic osteolysis

Targeting thymidine phosphorylase as a potential therapy for bone loss associated with periprosthetic osteolysis

Abstract Macrophages are generally thought to play a key role in the pathogenesis of aseptic loosening through initiating periprosthetic inflammation and pathological bone resorption. The aim of this study was to identify macrophage‐derived factors that promote osteoclast differentiation and peripro...

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Bibliographic Details
Main Authors: Gen Matsumae, Tomohiro Shimizu, Yuan Tian, Daisuke Takahashi, Taku Ebata, Hend Alhasan, Shunichi Yokota, Ken Kadoya, Mohamad Alaa Terkawi, Norimasa Iwasaki
Format: Article
Language:English
Published: Wiley 2021-09-01
Series:Bioengineering & Translational Medicine
Subjects:
aseptic loosening
kinase inhibitor
macrophage factors
TYMP
Online Access:https://doi.org/10.1002/btm2.10232

Internet

https://doi.org/10.1002/btm2.10232

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