The Second-Generation PIM Kinase Inhibitor TP-3654 Resensitizes ABCG2-Overexpressing Multidrug-Resistant Cancer Cells to Cytotoxic Anticancer Drugs

The Second-Generation PIM Kinase Inhibitor TP-3654 Resensitizes ABCG2-Overexpressing Multidrug-Resistant Cancer Cells to Cytotoxic Anticancer Drugs

Human ATP-binding cassette (ABC) subfamily G member 2 (ABCG2) mediates the transport of a wide variety of conventional cytotoxic anticancer drugs and molecular targeted agents. Consequently, the overexpression of ABCG2 in cancer cells is linked to the development of the multidrug resistance (MDR) ph...

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Bibliographic Details
Main Authors: Chung-Pu Wu, Yan-Qing Li, Ya-Chen Chi, Yang-Hui Huang, Tai-Ho Hung, Yu-Shan Wu
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
multidrug resistance
breast cancer resistance protein
modulator
TP-3654
SGI-9481
Online Access:https://www.mdpi.com/1422-0067/22/17/9440

Internet

https://www.mdpi.com/1422-0067/22/17/9440

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