Inhibition of Notch signaling in combination with paclitaxel reduces platinum-resistant ovarian tumor growth

Inhibition of Notch signaling in combination with paclitaxel reduces platinum-resistant ovarian tumor growth

Introduction: Ovarian cancer (OvCa) is the most lethal gynecologic malignancy in the United States because of chemoresistant recurrent disease. Our objective was to investigate the efficacy of inhibiting the Notch pathway with a gamma-secretase inhibitor (GSI) in an OvCa patient derived xenograft (...

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Bibliographic Details
Main Authors: Jolijn W Groeneweg, Celeste M DiGloria, Jing eYuan, William S Richardson, Whitfield B Growdon, Sriram eSathyanarayanan, Rosemary eFoster, Bo R Rueda
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-07-01
Series:Frontiers in Oncology
Subjects:
ovarian cancer
chemoresistance
Notch
patient derived xenografts
gamma secretase inhibitor
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00171/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00171/full

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