MHC-I molecules selectively inhibit cell-mediated cytotoxicity triggered by ITAM-coupled activating receptors and 2B4.

NK cell effector functions are controlled by a combination of inhibitory receptors, which modulate NK cell activation initiated by stimulatory receptors. Most of the canonical NK cell inhibitory receptors recognize allelic forms of classical and non-classical MHC class I molecules. Furthermore, high...

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Bibliographic Details
Main Authors: Rubén Corral-San Miguel, Trinidad Hernández-Caselles, Antonio José Ruiz Alcaraz, María Martínez-Esparza, Pilar García-Peñarrubia
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4166474?pdf=render