Synergism Through WEE1 and CHK1 Inhibition in Acute Lymphoblastic Leukemia

Synergism Through WEE1 and CHK1 Inhibition in Acute Lymphoblastic Leukemia

Introduction: Screening for synthetic lethality markers has demonstrated that the inhibition of the cell cycle checkpoint kinases WEE1 together with CHK1 drastically affects stability of the cell cycle and induces cell death in rapidly proliferating cells. Exploiting this finding for a possible ther...

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Bibliographic Details
Main Authors: Andrea Ghelli Luserna Di Rorà, Matteo Bocconcelli, Anna Ferrari, Carolina Terragna, Samantha Bruno, Enrica Imbrogno, Neil Beeharry, Valentina Robustelli, Martina Ghetti, Roberta Napolitano, Gabriella Chirumbolo, Giovanni Marconi, Cristina Papayannidis, Stefania Paolini, Chiara Sartor, Giorgia Simonetti, Timothy J. Yen, Giovanni Martinelli
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Cancers
Subjects:
acute lymphoblastic leukemia
synergism
dna damage response
wee1
chk1
Online Access:https://www.mdpi.com/2072-6694/11/11/1654

Internet

https://www.mdpi.com/2072-6694/11/11/1654

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