Ethanol-Dependent Synthesis of Salsolinol in the Posterior Ventral Tegmental Area as Key Mechanism of Ethanol’s Action on Mesolimbic Dopamine

Ethanol-Dependent Synthesis of Salsolinol in the Posterior Ventral Tegmental Area as Key Mechanism of Ethanol’s Action on Mesolimbic Dopamine

Abnormal consumption of ethanol, the ingredient responsible for alcoholic drinks’ addictive liability, causes millions of deaths yearly. Ethanol’s addictive potential is triggered through activation, by a still unknown mechanism, of the mesolimbic dopamine (DA) system, part of a key motivation circu...

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Bibliographic Details
Main Authors: Valentina Bassareo, Roberto Frau, Riccardo Maccioni, Pierluigi Caboni, Cristina Manis, Alessandra T. Peana, Rossana Migheli, Simona Porru, Elio Acquas
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Neuroscience
Subjects:
acetaldehyde
brain microdialysis
dopamine
ethanol
μ opioid receptors
nucleus accumbens shell
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.675061/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2021.675061/full

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