PARP-1/2 Inhibitor Olaparib Prevents or Partially Reverts EMT Induced by TGF-β in NMuMG Cells

PARP-1/2 Inhibitor Olaparib Prevents or Partially Reverts EMT Induced by TGF-β in NMuMG Cells

Poly- adenosine diphosphate (ADP)-ribose (PAR) is a polymer synthesized as a posttranslational modification by some poly (ADP-ribose) polymerases (PARPs), namely PARP-1, PARP-2, tankyrase-1, and tankyrase-2 (TNKS-1/2). PARP-1 is nuclear and has also been detected in extracellular vesicles. PARP-2 an...

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Bibliographic Details
Main Authors: Michelle Schacke, Janani Kumar, Nicholas Colwell, Kole Hermanson, Gustavo A. Folle, Sergei Nechaev, Archana Dhasarathy, Laura Lafon-Hughes
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:International Journal of Molecular Sciences
Subjects:
EMT
actin cytoskeleton
anisotropy
Poly(ADP-ribose)
PARP
PAR belt
olaparib
XAV939
MEO328
Online Access:https://www.mdpi.com/1422-0067/20/3/518

Internet

https://www.mdpi.com/1422-0067/20/3/518

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