Multimodality multiparametric imaging of early tumor response to a novel antiangiogenic therapy based on anticalins.
Anticalins are a novel class of targeted protein therapeutics. The PEGylated Anticalin Angiocal (PRS-050-PEG40) is directed against VEGF-A. The purpose of our study was to compare the performance of diffusion weighted imaging (DWI), dynamic contrast enhanced magnetic resonance imaging (DCE)-MRI and...
Main Authors: | Reinhard Meier, Rickmer Braren, Yvonne Kosanke, Johanna Bussemer, Frauke Neff, Moritz Wildgruber, Sarah Schwarzenböck, Annette Frank, Bernhard Haller, Andreas M Hohlbaum, Markus Schwaiger, Hendrik Gille, Ernst J Rummeny, Ambros J Beer |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4011746?pdf=render |
Similar Items
-
Different capacity of monocyte subsets to phagocytose iron-oxide nanoparticles.
by: Marcus Settles, et al.
Published: (2011-01-01) -
First-in-human phase I study of PRS-050 (Angiocal), an Anticalin targeting and antagonizing VEGF-A, in patients with advanced solid tumors.
by: Klaus Mross, et al.
Published: (2013-01-01) -
Assessing antiangiogenic therapy response by DCE-MRI: development of a physiology driven multi-compartment model using population pharmacometrics.
by: Andreas Steingoetter, et al.
Published: (2011-01-01) -
Multiparametric MR and PET Imaging of Intratumoral Biological Heterogeneity in Patients with Metastatic Lung Cancer Using Voxel-by-Voxel Analysis.
by: Stephan Metz, et al.
Published: (2015-01-01) -
Enhanced antitumor efficacy of a vascular disrupting agent combined with an antiangiogenic in a rat liver tumor model evaluated by multiparametric MRI.
by: Feng Chen, et al.
Published: (2012-01-01)