The HIV-1 Accessory Protein Vpu Downregulates Peroxisome Biogenesis

People living with HIV can experience accelerated aging and the development of neurological disorders. Recently, we reported that HIV-1 infection results in a dramatic loss of peroxisomes in macrophages and brain tissue. This is significant because (i) peroxisomes are important for the innate immune...

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Bibliographic Details
Main Authors: Zaikun Xu, Robert Lodge, Christopher Power, Eric A. Cohen, Tom C. Hobman
Format: Article
Language:English
Published: American Society for Microbiology 2020-03-01
Series:mBio
Subjects:
hiv
vpu
Online Access:https://doi.org/10.1128/mBio.03395-19