Backbone Cyclization and Dimerization of LL-37-Derived Peptides Enhance Antimicrobial Activity and Proteolytic Stability

Backbone Cyclization and Dimerization of LL-37-Derived Peptides Enhance Antimicrobial Activity and Proteolytic Stability

Can antimicrobial activity and peptide stability of alpha-helical peptides be increased by making them into dimers and macrocycles? Here, we explore that concept by using KR-12 as the starting point for peptide engineering. KR-12 has previously been determined as the minimalized antimicrobial fragme...

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Bibliographic Details
Main Authors: Sunithi Gunasekera, Taj Muhammad, Adam A. Strömstedt, K. Johan Rosengren, Ulf Göransson
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Microbiology
Subjects:
peptide cyclization
peptide dimerization
antimicrobial peptide
host defense
KR-12
LL-37
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.00168/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2020.00168/full

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