Activation of the alpha-globin gene expression correlates with dramatic upregulation of nearby non-globin genes and changes in local and large-scale chromatin spatial structure

Activation of the alpha-globin gene expression correlates with dramatic upregulation of nearby non-globin genes and changes in local and large-scale chromatin spatial structure

Abstract Background In homeotherms, the alpha-globin gene clusters are located within permanently open genome regions enriched in housekeeping genes. Terminal erythroid differentiation results in dramatic upregulation of alpha-globin genes making their expression comparable to the rRNA transcription...

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Bibliographic Details
Main Authors: Sergey V. Ulianov, Aleksandra A. Galitsyna, Ilya M. Flyamer, Arkadiy K. Golov, Ekaterina E. Khrameeva, Maxim V. Imakaev, Nezar A. Abdennur, Mikhail S. Gelfand, Alexey A. Gavrilov, Sergey V. Razin
Format: Article
Language:English
Published: BMC 2017-07-01
Series:Epigenetics & Chromatin
Subjects:
Alpha-globin genes
Transcription
CTCF
Chromatin spatial structure
TAD
Chromatin compartment
Online Access:http://link.springer.com/article/10.1186/s13072-017-0142-4

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http://link.springer.com/article/10.1186/s13072-017-0142-4

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