Activation of the alpha-globin gene expression correlates with dramatic upregulation of nearby non-globin genes and changes in local and large-scale chromatin spatial structure
Abstract Background In homeotherms, the alpha-globin gene clusters are located within permanently open genome regions enriched in housekeeping genes. Terminal erythroid differentiation results in dramatic upregulation of alpha-globin genes making their expression comparable to the rRNA transcription...
Main Authors: | Sergey V. Ulianov, Aleksandra A. Galitsyna, Ilya M. Flyamer, Arkadiy K. Golov, Ekaterina E. Khrameeva, Maxim V. Imakaev, Nezar A. Abdennur, Mikhail S. Gelfand, Alexey A. Gavrilov, Sergey V. Razin |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2017-07-01
|
Series: | Epigenetics & Chromatin |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s13072-017-0142-4 |
Similar Items
-
Spatial organization of the chicken beta-globin gene domain in erythroid cells of embryonic and adult lineages
by: Ulianov Sergey V, et al.
Published: (2012-09-01) -
The Role of GLP Domains in Spreading of the G9a/GLP Complex and Regulation of the β-globin Gene Expression
by: Thieba, Camilia Annik
Published: (2012) -
The Role of GLP Domains in Spreading of the G9a/GLP Complex and Regulation of the β-globin Gene Expression
by: Thieba, Camilia Annik
Published: (2012) -
Sensitivity of cohesin–chromatin association to high-salt treatment corroborates non-topological mode of loop extrusion
by: Arkadiy K. Golov, et al.
Published: (2021-07-01) -
Chromatin States in Mouse Sperm Correlate with Embryonic and Adult Regulatory Landscapes
by: Yoon Hee Jung, et al.
Published: (2017-02-01)