Intestinal Goblet Cell Loss during Chorioamnionitis in Fetal Lambs: Mechanistic Insights and Postnatal Implications

Intestinal Goblet Cell Loss during Chorioamnionitis in Fetal Lambs: Mechanistic Insights and Postnatal Implications

Chorioamnionitis, an important cause of preterm birth, is linked to necrotizing enterocolitis (NEC). NEC is characterized by a disrupted mucus barrier, goblet cell loss, and endoplasmic reticulum (ER) stress of the intestinal epithelium. These findings prompted us to investigate the mechanisms under...

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Bibliographic Details
Main Authors: Charlotte van Gorp, Ilse H. de Lange, Kimberly R. I. Massy, Lilian Kessels, Alan H. Jobe, Jack P. M. Cleutjens, Matthew W. Kemp, Masatoshi Saito, Haruo Usada, John Newnham, Matthias Hütten, Boris W. Kramer, Luc J. Zimmermann, Tim G. A. M. Wolfs
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
ER stress
perinatal
mucus barrier
intestinal inflammation
Online Access:https://www.mdpi.com/1422-0067/22/4/1946

Internet

https://www.mdpi.com/1422-0067/22/4/1946

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