Targeting of PI3K/AKT/mTOR pathway to inhibit T cell activation and prevent graft-versus-host disease development

Targeting of PI3K/AKT/mTOR pathway to inhibit T cell activation and prevent graft-versus-host disease development

Abstract Background Graft-versus-host disease (GvHD) remains the major obstacle to successful allogeneic hematopoietic stem cell transplantation, despite of the immunosuppressive regimens administered to control T cell alloreactivity. PI3K/AKT/mTOR pathway is crucial in T cell activation and functio...

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Bibliographic Details
Main Authors: Mª Carmen Herrero-Sánchez, Concepción Rodríguez-Serrano, Julia Almeida, Laura San Segundo, Susana Inogés, Ángel Santos-Briz, Jesús García-Briñón, Luis Antonio Corchete, Jesús F. San Miguel, Consuelo del Cañizo, Belén Blanco
Format: Article
Language:English
Published: BMC 2016-10-01
Series:Journal of Hematology & Oncology
Subjects:
Hematopoietic stem cell transplantation
Graft-versus-host disease
T cell
PI3K/AKT/mTOR pathway
PI3K inhibitor
Online Access:http://link.springer.com/article/10.1186/s13045-016-0343-5

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http://link.springer.com/article/10.1186/s13045-016-0343-5

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