In silico evaluation of rare codons and their positions in the structure of cytosine deaminase and substrate docking studies

In silico evaluation of rare codons and their positions in the structure of cytosine deaminase and substrate docking studies

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Cytosine deaminase (CDase) is used with 5-fluorocytosine (5FC) for genetic cancer treatment. This approach has several undesirable features, such as a relatively poor turnover of 5FC and low prodrug conversion activities, thus limiting the overall therapeutic response. We previously reported the mol...

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Bibliographic Details
Main Authors: Mojtaba Mortazavi, Navid Nezafat, Manica Negahdaripour, Ahmad Gholami, Masoud Torkzadeh-Mahani, Safa Lotfi, Younes Ghasemi
Format: Article
Language:English
Published: Shiraz University of Medical Sciences 2016-06-01
Series:Trends in Pharmaceutical Sciences
Subjects:
autodock
bioinformatics analysis
cdase
rare codon
Online Access:https://tips.sums.ac.ir/article_42191_f545b94a62319c431688f3b3e3bd61bc.pdf

Internet

https://tips.sums.ac.ir/article_42191_f545b94a62319c431688f3b3e3bd61bc.pdf

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