Intra-aortic clusters undergo endothelial to hematopoietic phenotypic transition during early embryogenesis.

Intra-aortic clusters (IACs) attach to floor of large arteries and are considered to have recently acquired hematopoietic stem cell (HSC)-potential in vertebrate early mid-gestation embryos. The formation and function of IACs is poorly understood. To address this issue, IACs were characterized by im...

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Bibliographic Details
Main Authors: Chiyo Mizuochi, Stuart T Fraser, Katia Biasch, Yuka Horio, Yoshikane Kikushige, Kenzaburo Tani, Koichi Akashi, Manuela Tavian, Daisuke Sugiyama
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3338791?pdf=render