HDAC2 Inhibitor Valproic Acid Increases Radiation Sensitivity of Drug-Resistant Melanoma Cells

HDAC2 Inhibitor Valproic Acid Increases Radiation Sensitivity of Drug-Resistant Melanoma Cells

Resistance to anticancer drugs limits the effectiveness of chemotherapy in cancers. Melanoma cell lines B16F10C and A375C (parental) and B16F10R and A375R (drug-resistant sublines) were used to test radiation sensitization potential of valproic acid (VPA), an inhibitor of Histone deacetylase2 (HDAC2...

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Bibliographic Details
Main Authors: Bhuvanesh Sukhlal Kalal, Vinitha Ramanath Pai, Santosh Kumar Behera, Hiriyur Mallaiah Somashekarappa
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Medical Sciences
Subjects:
cytotoxic
drug-resistance
histone deacetylase 2
melanoma
radiosensitizer
valproic acid
Online Access:https://www.mdpi.com/2076-3271/7/3/51

Internet

https://www.mdpi.com/2076-3271/7/3/51

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