Stabilization of c-KIT G-Quadruplex DNA Structures by the RNA Polymerase I Inhibitors BMH-21 and BA-41

Stabilization of c-KIT G-Quadruplex DNA Structures by the RNA Polymerase I Inhibitors BMH-21 and BA-41

The stabilization of G-quadruplex DNA structures by small molecules with affinity to oncogene promoters has emerged as a promising anticancer strategy, due to a potential role in gene expression regulation. We explored the ability of BMH-21 (<b>1</b>) and its analogue BA-41 (<b>2&l...

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Bibliographic Details
Main Authors: Stefania Mazzini, Raimundo Gargallo, Loana Musso, Francesca De Santis, Anna Aviñó, Leonardo Scaglioni, Ramon Eritja, Massimo Di Nicola, Franco Zunino, Annabella Amatulli, Sabrina Dallavalle
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:International Journal of Molecular Sciences
Subjects:
c-kit
g-quadruplex
pyridoquinazolinone derivatives
cd
nmr spectroscopy
Online Access:https://www.mdpi.com/1422-0067/20/19/4927

Internet

https://www.mdpi.com/1422-0067/20/19/4927

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