MAPT subhaplotypes in corticobasal degeneration: assessing associations with disease risk, severity of tau pathology, and clinical features

MAPT subhaplotypes in corticobasal degeneration: assessing associations with disease risk, severity of tau pathology, and clinical features

Abstract The microtubule-associated protein tau (MAPT) H1 haplotype is the strongest genetic risk factor for corticobasal degeneration (CBD). However, the specific H1 subhaplotype association is not well defined, and it is not clear whether any MAPT haplotypes influence severity of tau pathology or...

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Bibliographic Details
Main Authors: Rebecca R. Valentino, Shunsuke Koga, Ronald L. Walton, Alexandra I. Soto-Beasley, Naomi Kouri, Michael A. DeTure, Melissa E. Murray, Patrick W. Johnson, Ronald C. Petersen, Bradley F. Boeve, Ryan J. Uitti, Zbigniew K. Wszolek, Dennis W. Dickson, Owen A. Ross, Michael G. Heckman
Format: Article
Language:English
Published: BMC 2020-12-01
Series:Acta Neuropathologica Communications
Subjects:
Corticobasal degeneration
MAPT
Genetics
Neuropathology
Online Access:https://doi.org/10.1186/s40478-020-01097-z

Internet

https://doi.org/10.1186/s40478-020-01097-z

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