Dissociating orexin-dependent and -independent functions of orexin neurons using novel Orexin-Flp knock-in mice

Dissociating orexin-dependent and -independent functions of orexin neurons using novel Orexin-Flp knock-in mice

Uninterrupted arousal is important for survival during threatening situations. Activation of orexin/hypocretin neurons is implicated in sustained arousal. However, orexin neurons produce and release orexin as well as several co-transmitters including dynorphin and glutamate. To disambiguate orexin-d...

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Bibliographic Details
Main Authors: Srikanta Chowdhury, Chi Jung Hung, Shuntaro Izawa, Ayumu Inutsuka, Meiko Kawamura, Takashi Kawashima, Haruhiko Bito, Itaru Imayoshi, Manabu Abe, Kenji Sakimura, Akihiro Yamanaka
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-06-01
Series:eLife
Subjects:
orexin/hypocretin
flippase recombinase
electrophysiology
chemogenetics
sleep/wakefulness
cataplexy
Online Access:https://elifesciences.org/articles/44927

Internet

https://elifesciences.org/articles/44927

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