The alternative Epac/cAMP pathway and the MAPK pathway mediate hCG induction of leptin in placental cells.

The alternative Epac/cAMP pathway and the MAPK pathway mediate hCG induction of leptin in placental cells.

Pleiotropic effects of leptin have been identified in reproduction and pregnancy, particularly in the placenta, where it works as an autocrine hormone. In this work, we demonstrated that human chorionic gonadotropin (hCG) added to JEG-3 cell line or to placental explants induces endogenous leptin ex...

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Bibliographic Details
Main Authors: Julieta Lorena Maymó, Antonio Pérez Pérez, Bernardo Maskin, José Luis Dueñas, Juan Carlos Calvo, Víctor Sánchez Margalet, Cecilia Laura Varone
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3462743?pdf=render

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http://europepmc.org/articles/PMC3462743?pdf=render

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