Apatinib induces endoplasmic reticulum stress-mediated apoptosis and autophagy and potentiates cell sensitivity to paclitaxel via the IRE-1α–AKT–mTOR pathway in esophageal squamous cell carcinoma

Apatinib induces endoplasmic reticulum stress-mediated apoptosis and autophagy and potentiates cell sensitivity to paclitaxel via the IRE-1α–AKT–mTOR pathway in esophageal squamous cell carcinoma

Abstract Background Apatinib, a novel vascular endothelial growth factor receptor-2 (VEGFR-2) tyrosine kinase inhibitor, has been approved for the treatment of metastatic gastric cancer and other tumors. Apatinib exerts antiproliferative and proapoptotic effects in different kinds of cancer cells. H...

Full description

Bibliographic Details
Main Authors: Yu-Ming Wang, Xin Xu, Jian Tang, Zhi-Yong Sun, Yu-Jie Fu, Xiao-Jing Zhao, Xiu-Mei Ma, Qing Ye
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Cell & Bioscience
Subjects:
Apatinib
ER stress
Autophagy
Apoptosis
Paclitaxel
Esophageal squamous cell carcinoma
Online Access:https://doi.org/10.1186/s13578-021-00640-2

Internet

https://doi.org/10.1186/s13578-021-00640-2

Similar Items