Structure and function of parkin, PINK1 and DJ-1, the three musketeers of neuroprotection
Autosomal recessive forms of Parkinson’s disease are caused by mutations in three genes: Parkin, PINK1 and DJ-1. These genes encode for proteins with distinct enzymatic activities that may work together to confer neuroprotection. Parkin is an E3 ubiquitin ligase that has been shown to ubiquitinate s...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2013-04-01
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| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fneur.2013.00038/full |