Contribution of human FcγRs to disease with evidence from human polymorphisms and transgenic animal studies

The biological activities of human IgG antibodies predominantly rely on a family of receptors for the Fc portion of IgG, FcγRs: FcγRI, FcγRIIA, FcγRIIB, FcγRIIC, FcγRIIIA, FcγRIIIB, FcRL5, FcRn and TRIM21. All FcγRs bind IgG at the cell surface, except FcRn and TRIM21 that bind IgG once internalized...

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Bibliographic Details
Main Authors: Caitlin Margaret Gillis, Aurélie eGouel-Chéron, Friederike eJönsson, Pierre eBruhns
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-05-01
Series:Frontiers in Immunology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00254/full