Contribution of human FcγRs to disease with evidence from human polymorphisms and transgenic animal studies

Contribution of human FcγRs to disease with evidence from human polymorphisms and transgenic animal studies

The biological activities of human IgG antibodies predominantly rely on a family of receptors for the Fc portion of IgG, FcγRs: FcγRI, FcγRIIA, FcγRIIB, FcγRIIC, FcγRIIIA, FcγRIIIB, FcRL5, FcRn and TRIM21. All FcγRs bind IgG at the cell surface, except FcRn and TRIM21 that bind IgG once internalized...

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Bibliographic Details
Main Authors: Caitlin Margaret Gillis, Aurélie eGouel-Chéron, Friederike eJönsson, Pierre eBruhns
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-05-01
Series:Frontiers in Immunology
Subjects:
Anaphylaxis
Autoimmune Diseases
IgG receptors
Transgenic mice
Genetic polymorphisms and disease association.
human IgG receptors
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00254/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00254/full

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