Contribution of human FcγRs to disease with evidence from human polymorphisms and transgenic animal studies
The biological activities of human IgG antibodies predominantly rely on a family of receptors for the Fc portion of IgG, FcγRs: FcγRI, FcγRIIA, FcγRIIB, FcγRIIC, FcγRIIIA, FcγRIIIB, FcRL5, FcRn and TRIM21. All FcγRs bind IgG at the cell surface, except FcRn and TRIM21 that bind IgG once internalized...
Main Authors: | Caitlin Margaret Gillis, Aurélie eGouel-Chéron, Friederike eJönsson, Pierre eBruhns |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2014-05-01
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Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00254/full |
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