Essential Roles of SATB1 in Specifying T Lymphocyte Subsets

Essential Roles of SATB1 in Specifying T Lymphocyte Subsets

T cell receptor (TCR) signaling by MHC class I and II induces thymocytes to acquire cytotoxic and helper fates via the induction of Runx3 and ThPOK transcription factors, respectively. The mechanisms by which TCR signaling is translated into transcriptional programs for each cell fate remain elusive...

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Bibliographic Details
Main Authors: Kiyokazu Kakugawa, Satoshi Kojo, Hirokazu Tanaka, Wooseok Seo, Takaho A. Endo, Yohko Kitagawa, Sawako Muroi, Mari Tenno, Nighat Yasmin, Yoshinori Kohwi, Shimon Sakaguchi, Terumi Kowhi-Shigematsu, Ichiro Taniuchi
Format: Article
Language:English
Published: Elsevier 2017-05-01
Series:Cell Reports
Subjects:
T lymphocyte development
lineage specification
gene regulation
genome organizer
SATB1
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717305326

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http://www.sciencedirect.com/science/article/pii/S2211124717305326

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