Efficacy of sertraline against Trypanosoma cruzi: an in vitro and in silico study

Efficacy of sertraline against Trypanosoma cruzi: an in vitro and in silico study

Abstract Background Drug repurposing has been an interesting and cost-effective approach, especially for neglected diseases, such as Chagas disease. Methods In this work, we studied the activity of the antidepressant drug sertraline against Trypanosoma cruzi trypomastigotes and intracellular amastig...

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Main Authors: Daiane Dias Ferreira, Juliana Tonini Mesquita, Thais Alves da Costa Silva, Maiara Maria Romanelli, Denise da Gama Jaen Batista, Cristiane França da Silva, Aline Nefertiti Silva da Gama, Bruno Junior Neves, Cleber Camilo Melo-Filho, Maria de Nazare Correia Soeiro, Carolina Horta Andrade, Andre Gustavo Tempone
Format: Article
Language:English
Published: SciELO 2018-10-01
Series:Journal of Venomous Animals and Toxins including Tropical Diseases
Subjects:
Trypanosoma cruzi
Drug
Treatment
Sertraline
Drug repurposing
Drug repositioning
Online Access:http://link.springer.com/article/10.1186/s40409-018-0165-8

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http://link.springer.com/article/10.1186/s40409-018-0165-8

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